Razgradnja 17ß-estradiola u vodi UV-C/H2O2 procesom

undergraduate thesis

• Title (english): Degradation of 17ß-estradiol in water by UV-C/H2O2 process
• Author: Anja Pintar
• Mentor: Hrvoje Kušić (mentor)
• Committee member: Hrvoje Kušić (predsjednik povjerenstva)
• Committee member: Ana Lončarić Božić (član povjerenstva)
• Committee member: Martina Biošić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2015-09-14, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering; Environmental Protection in Chemical Engineering

Abstract

Lijekovi izazivaju zabrinutost zbog svoje sveprisutnosti u vodi i učinaka na zdravlje.
Budući da primarne i sekundarne tehnologije obrade otpadnih voda nisu dizajnirane za
uklanjanje nekih od prioritetnih onečišćivala i njihovih metabolita, farmaceutici su otkriveni u
različitim ekološkim sredinama diljem svijeta; u otpadnim vodama postrojenja za obradu
otpadnih voda, te u površinskim, podzemnim i pitkim vodama. Aktualna Direktiva
2013/39/EU uključila je farmaceutski spoj 17β-estradiol (E2) na tzv. „watch“ listu. 17β-
estradiol je ženski spolni hormon i steroid koji se nalazi u lijekovima te u vrlo malim
koncentracijama može imati štetne učinke na različite organizme. Kako konvencionalni
sustavi za pročišćavanje nisu u potpunosti učinkoviti pri uklanjanju E2 te kako bi se riješio taj
problem potrebno je razviti nove tehnologije koje mogu u potpunosti ukloniti ili uništiti
njegovu biološku aktivnost. Cilj ovog istraživanja bio je procijeniti mogućnosti naprednih
oksidacijskih procesa, posebno fotooksidativnih procesa UV-C/H2O2 i za tretiranje modelne
otpadne vode koja sadrži E2 otopljen u vodenoj otopini acetonitrila. Ispitan je utjecaj pH i
koncentracije H2O2 na brzinu razgradnje E2, korištenjem punog faktorskog plana i metode
odzivnih površina (RSM). Kinetika razgradnje E2 opisana je modelom prvoga reda te
razvijenim RSM modelom u kojemu su pH i koncentracija H2O2 utvrđeni značajnima za
učinkovitost razgradnje E2. Dobivene vrijednosti konstanti brzine razgradnje (kobs) kretale su
se od 8,066 × 10-4 s-1 do 40,74 × 10-4 s-1. Optimalni uvjeti pri kojima se postiže najveća brzina
razgradnje je pri pH = 7 uz [H2O2] = 50 mM.

Abstract (english)

The pharmaceuticals are of particular concern due to their ubiquity in the aquatic
environment and their health effects. Since primary and secondary wastewater treatment
(WWT) technologies are not specifically designed to remove some of contaminants of
emerging concern (CECs) and their metabolites, pharmaceuticals are detected in different
environmental matrices worldwide; in WWT plant effluents, surface, ground and drinking
waters. Current Directive 2013/39 / EC included the pharmaceutical 17β-estradiol (E2) in the
"watch" list. 17β-Estradiol is a female sex hormone and steroid drug which can have adverse
effects on various organisms at very low concentrations. Because WWT systems are not fully
effective in removing E2, in order to solve this problem it is necessary to develop new
technologies that can completely remove or destroy its biological activity. The aim of this
study was to evaluate the possibilities of advanced oxidation processes, especially
photooxidative process UV-C/H2O2 model for treating model wastewater containing E2
dissolved in aqueous acetonitrile. The influence of key operating parameters of applied
photooxidative processes (pH and concentration of oxidant) were investigated using the
combination of full factorial experimental design. The influence of pH and concentration of
H2O2 on the kinetics of E2 degradation were experimentally evaluated. Degradation of E2
obeys first-order kinetics, which was accurately modeled by the developed RSM model which
takes into account the pH and concentration of H2O2. Observed reaction rates were in the
range from 8.066 × 10-4 s-1 to 40.74 × 10-4 s-1. The optimal conditions yielding the highest
degradation rate were at pH 7 and [H2O2] = 50 mM.

• Keywords: farmaceutici; 17β-estradiol; fotooksidacijski procesi
• Keywords (english): pharmaceuticals; 17β-estradiol; photooxidation process
• Language: croatian
• URN:NBN: urn:nbn:hr:149:076061
• Study programme: Title: Environmental Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka ekoinženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb
• Created on: 2016-11-25 10:00:43