Zadovoljstvo bolesnika antikoagulacijskom terapijom varfarinom

master's thesis

• Title (english): Patient satisfaction with anticoagulant warfarin therapy
• Author: Martina Drljanovčan
• Mentor: Maja Ortner Hadžiabdić (mentor)
• Committee member: Maja Ortner Hadžiabdić (predsjednik povjerenstva)
• Committee member: Lidija Bach-Rojecky (član povjerenstva)
• Committee member: Dubravka Vitali Čepo (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Centre for applied pharmacy); Zagreb
• Defense date and country: 2016-09-27, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Varfarin je oralni antikoagulans koji se najčešće koristi u prevenciji tromboembolijskih komplikacija i duboke
venske tromboze u pacijenata s atrijskom fibrilacijom ili venskom tromboembolijom. Kronična uporaba ovog
lijeka zahtjeva od pacijenta veliki angažman i samokontrolu te može uvelike utjecati na percepciju kvalitete života.
DASS (Duke Anticoagulation Satisfaction Scale) upitnik osmišljen je kako bi se izmjerilo zadovoljstvo liječenja i
kvaliteta života u pacijenata na terapiji oralnim antikoagulansima.
Cilj ovog istraživanja bio je izmjeriti zadovoljstvo pacijenata na antikoagulacijskoj terapiji varfarinom uz pomoć
DASS upitnika i dodatno istražiti pacijentovo razumijevanje terapije. Presječno opservacijsko istraživanje bilo je
provedeno je od ožujka do lipnja 2016. godine s javnim ljekarnama na području Zagreba i Velike Gorice. U
istraživanje su bili uključeni punoljetni pacijenti na terapiji varfarinom duže od tri mjeseca.
Za svakog ispitanika prikupljeni su demografski i relevantni klinički podaci te su pacijenti ispunili DASS upitnik.
Etičko povjerenstvo Farmaceutsko-biokemijskog fakulteta Sveučilišta u Zagrebu odobrilo je provedbu ovog
istraživanja.
U studiju je bilo uključeno 60 pacijenta prosječne dobi 68,12 (± 11,96) godina (raspon 31-85) koji su u prosjeku
koristili 5,35 (± 3,13) lijekova (raspon 1-14). Zbrojem bodova svih 25 pitanja DASS upitnika izmjereno je ukupno
zadovoljstvo pacijenata na antikoagulacijskoj terapiji, a mogući raspon bodova kretao se od 25–175 (25 – najviši
stupanj zadovoljstva; 175 – najniži stupanj zadovoljstva). Prosječna vrijednost zbroja DASS-a ispitivanog uzorka
iznosila je 54,55 (± 18,75), što ukazuje na prilično visok stupanj zadovoljstva. Osim zadovoljstva pacijenata,
analizirana je i povezanost DASS rezultata s demografskim i općim podacima. Proučavani podaci pokazali su
statistički značajnu razliku u zadovoljstvu ispitanika u odnosu na spol te je zadovoljstvo muškaraca
antikoagulacijskom terapijom varfarinom bilo veće nego u žena (p<0,008).
Ovo istraživanje je po prvi puta na uzorku hrvatske populacije istražilo zadovoljstvo i kvalitetu života pacijenata na
terapiji varfarinom korištenjem hrvatske verzije DASS upitnika i time dalo preliminarne rezultate (dobivene na
malom uzorku) o utjecaju terapije varfarina na kvalitetu života pacijenata.

Abstract (english)

Warfarin is an oral anticoagulant that is mostly used for the prevention of thromboembolism complications and
deep vein thrombosis in patients with atrial fibrillation or venous thromboembolism. Chronic use of this
medication requires great commitment and self-control and can greatly affect patient's perception of quality of
life. DASS (Duke Anticoagulation Satisfaction Scale) questionnaire is designed to measure treatment
satisfaction and quality of life in patients treated with oral anticoagulants.
The aim of this study was to measure the satisfaction of patients on anticoagulant therapy with warfarin with
the help of DASS questionnaire and to study further the patient's understanding of therapy. A cross-sectional
observational study was conducted from March to June 2016 in collaboration with public pharmacies from
Zagreb and VelikaGorica. The study involved adult patients who had been on warfarin therapy for more than
three months.
For each examinee demographic and relevant clinical data were gathered and patients fulfilled the DASS
questionnaire. The Ethics Committee from the Faculty of Pharmacy and Biochemistry from University of
Zagreb has approved the implementation of this study.
The study included 60 patients with an average age of 68.12 (± 11.96) years (range 31-85) that used an average
of 5.35 (± 3.13) drugs (range 1-14). The total of 25 questions in DASS questionnaire measured the overall
satisfaction in patients on anticoagulants, with possible range of points ranged from 25 to 175 (25 - the highest
level of satisfaction; 175 - the lowest level of satisfaction).
The average value of the sum of the DASS test sample was 54.55 (± 18.75), indicating a fairly high level of
satisfaction. In addition to patient satisfaction, we analysed the connection of DASS results with demographic
and general data. Obtained material showed a statistically significant difference in the satisfaction of examinees
with respect to sex, concluding that satisfaction with warfarin anticoagulation therapy in men was greater than
in women (p <0.008).
This research was executed for the first time using the Croatian version of the DASS questionnaire on the
Croatian population with the aim to investigate satisfaction and quality of life of patients on warfarin therapy
and thus gave preliminary results (obtained on a small sample) on the impact that warfarin therapy has on the
quality of patients’ lives.

• Keywords: varfarin; antikoagulans
• Keywords (english): warfarin; anticoagulant
• Language: croatian
• URN:NBN: urn:nbn:hr:163:784324
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb
• Created on: 2017-09-14 13:39:23