Mikrorazinski studij fenomena granuliranja primjenom parametara međupovršine prašak-vezivo

undergraduate thesis

• Title (english): The micro scale study of granulation phenomenon using parameters of powder-binder interface
• Author: Ivona Košić
• Mentor: Krunoslav Žižek (mentor)
• Committee member: Krunoslav Žižek (predsjednik povjerenstva)
• Committee member: Gordana Matijašić (član povjerenstva)
• Committee member: Mirela Leskovac (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2016-07-13, Croatia
• Scientific / art field, discipline and subdiscipline: TECHNICAL SCIENCES; Chemical Engineering; Mechanical, Thermal and Separation Processes

Abstract

U ovome je radu sagledano granuliranje dviju pomoćnih tvari farmaceutske industrije u fluidiziranom sloju s taljenjem sa stajališta mikrorazine procesa. Testovi šaržnog granuliranja provedeni su prethodnim istraživanjem u procesnoj geometriji fluidiziranog sloja u laboratorijskom mjerilu. U fizičkoj pretvorbi tvari korišteno je vezivo, praškasti polietilen glikol koji taljenjem osigurava nužna kapljevita premoštenja. Mikrorazinski studij fenomena granuliranja usmjeren je k pronalaženju parametara međupovršine prašak-vezivo za sustave mikrokristalna celuloza/polietilen glikol i laktoza monohidrat/polietilen glikol. U karakterizaciji dviju međupovršina od značaja korištena je eksperimentalna tehnika mjerenja kontaktnog kuta goniometrom. Određeni su kontaktni kutovi triju testnih kapljevina poznatih energija površina na supstratima mikrokristalne celuloze, laktoze monohidrata i polietilen glikola. U kvantitativnom predviđanju interakcija korišteni su dvoparametarski modeli. Primjenom Owens-Wendtova i Wuova modela procijenjene su slobodne energije površina pojedinih faza, energije međupovršina od značaja te pripadajuće vrijednosti termodinamičkog rada adhezije i koeficijenta kvašenja. Parametri adhezije ukazuju na slabe interakcije između mikrokristalne celuloze i polietilen glikola te mogućnost odvajanja faza i posljedično na nemogućnost granuliranja ovog sustava. Dodatno, parametri međupovršine ukazuju na mogućnost uspostave značajnih interakcija između laktoze monohidrata i polietilen glikola.

Abstract (english)

In this thesis, fluidized bed melt granulation of two pharmaceutical excipients is scrutinized from a micro scale level of scrutiny. Batch granulation tests were performed by previous research in process geometry of fluidized bed in a lab-scale. Binder, polyethylene glycol powder that provides necessary liquid bridges by melting, is used in physical conversion of a substance. The micro scale study of granulation phenomenon is focused towards detection of parameters of powder-binder interface for systems microcrystalline cellulose/polyethylene glycol and lactose monohydrate/polyethylene glycol. Experimental technique for measurement of contact angle using goniometer is used for characterization of two interfaces of interest. Contact angles of three test liquids with well known surface energies were determined on substrates of microcrystalline cellulose, lactose monohydrate and polyethylene glycol. Two parametric models were used for quantitative prediction of interactions. Surface free energies for each phase, interfacial energies of interest and corresponding values of thermodynamic work of adhesion and spreading coefficient were estimated using Owens-Wendt and Wu model. Adhesion parameters indicate weak interactions between microcrystalline cellulose and polyethylene glycol with possibility of phase dewetting and consequently on the inability for granulation of this system. Additionally, interface parameters indicate the possibility for establishment of considerable interactions between lactose monohydrate and polyethylene glycol.

• Keywords: granuliranje u fluidiziranom sloju s taljenjem; pomoćna tvar; vezivo; mikrorazina procesa; parametri međupovršine prašak-vezivo
• Keywords (english): fluidized bed melt granulation; excipient; binder; micro scale of process; parameters of powder-binder interface
• Language: croatian
• URN:NBN: urn:nbn:hr:149:002056
• Study programme: Title: Applied Chemistry - Undergraduate study; specializations in: Environmental chemistry and green technologies, Advanced materials and technologies, Applied organic chemistry; Course: Advanced materials and technologies; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) primijenjene kemije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb
• Created on: 2017-12-11 09:52:29