Sorpcija farmaceutika na otpadni mulj

undergraduate thesis

• Title (english): Sorption of pharmaceuticals in waste sludge
• Author: Anela Udovčić
• Mentor: Dragana Mutavdžić Pavlović (mentor)
• Committee member: Dragana Mutavdžić Pavlović (predsjednik povjerenstva)
• Committee member: Tatjana Gazivoda Kraljević (član povjerenstva)
• Committee member: Ivan Brnardić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Chemical Engineering and Technology; Zagreb
• Defense date and country: 2015-05-26, Croatia
• Scientific / art field, discipline and subdiscipline: NATURAL SCIENCES; Chemistry; Analytic Chemistry

Abstract

Humani i veterinarski lijekovi uslijed kontinuiranih proizvodnih procesa, stalno pronalaze svoje mjesto u okolišu, uglavnom kao rezultat istih, ili uslijed odlaganja neiskorištenih ili zastarjelih proizvoda i izlučevina. Zbog svojih fizikalno-kemijskih svojstava, mnogi od tih supstanci ili njihovih bioaktivnih metabolita, mogu završiti u tlu i sedimentu, gdje akumulacijom izazivaju neželjene učinke kod kopnenih ili vodenih organizama. Među tim učincima, javlja se i rast otpornosti bakterija uzrokovan velikom uporabom antibiotika u liječenju ljudi i životinja, te dodavanjem gnojiva i kanalizacijskog mulja na poljoprivrednim područjima, što je od posebne važnosti.

Rastom svijesti o prisutnosti i djelovanju farmaceutika u okolišu, javlja se potreba za sve većom pažnjom i nadzorom istih, te uspostavljanjem zakonskih regulativa, ali i pronalaskom i optimiziranjem analitičkih metoda kvalitativnog i kvantitativnog određivanja kao i metoda njihovog uklanjanja iz okoliša.

Budući da konvencionalne metode uklanjanja farmaceutika ne daju željene rezultate, potrebno je pristupiti usavršavanju postojećih i razvoju novih metoda. Sorpcija je jedan od procesa koji bi se mogao iskoristiti za uklanjanje farmaceutika iz otpadnih voda, pa samim time i iz okoliša.

Cilj ovoga rada je odrediti pogodnost neutralizacijskog mulja, nastalog u postupku neutralizacije iscrpljene sulfatno kisele kupke, kao sorbensa za uklanjanje antibiotika ciprofloksacina iz otpadnih voda. Kao metoda određivanja preostalog ciprofloksacina u uzorcima vode nakon sorpcije korištena je UV/VIS spektrofotometrija. Određeni su sorpcijski koeficijenti ciprofloksacina linearnom regresijom primjenom Freundlichovog i Langmuirovog sorpcijskog modela. Također je određen utjecaj temperature, pH vrijednosti, ionske jakosti i mase mulja na sorpciju. Osim neutralizacijskog mulja, svi eksperimenti su provedeni i s toplinski obrađenim neutralizacijskim muljem. Na taj način željelo se vidjeti da li se toplinskom obradom neutralizacijskog mulja pospješuje sorpcija ispitivanog farmaceutika.

Abstract (english)

Human and veterinary medicines are constantly finding their place in the environment due to continuous production processes, mainly as a result thereof, or by disposal of unused or obsolete products and secretions. Due to their physico-chemical properties, many of these substances or their bioactive metabolites, may end up in soil and sediments, where accumulation might occure adverse effects in terrestrial or aquatic organisms. Among these effects, there is the growth of bacterial resistance caused by the extensive use of animal's antibiotics, adding manure and sewage sludge on agricultural fields, which is of particular importance.

With increasing awareness of the presence and action of pharmaceuticals in the environment, there is a need for increasing attention and supervision thereof, and establishing a legal framework, but also for the discovery and optimization of analytical methods of qualitative and quantitative determinations. Since conventional methods of removing pharmaceuticals do not provide the desired results, it is necessary to improving existing and developing new methods. Sorption is one of the processes that could be used to remove pharmaceuticals from wastewater, and therefore also of the environment.

The aim of this study was to determine the suitability of neutralization sludge generated in the process of neutralization exhausted sulphate acid bath, as sorbent for the removal of antibiotic ciprofloxacin from wastewater. As a method for determination of remaining ciprofloxacin in water samples after sorption was used UV/VIS spectrophotometry. Sorption coefficients of ciprofloxacin were determined using the linear regression of Freundlich and Langmuir sorption models. It was also determined the effect of temperature, pH, ionic strength and weight of the sludge on sorption process. Besides neutralization sludge, all experiments were performed with heat-treated neutralization sludge. In this way, we wanted to see whether the thermal treatment of neutralization sludge enhances the sorption of investigated pharmaceutical.

• Keywords: farmaceutici u okolišu; otpadne vode farmaceutske industrije; sorpcija; ciprofloksacin; UV/VIS spektrofotometrija
• Keywords (english): pharmaceuticals in the environment; pharmaceutical industry wastewater; sorption; ciprofloxacin; UV/VIS spectrophotometry
• Language: croatian
• URN:NBN: urn:nbn:hr:149:188756
• Study programme: Title: Chemical Engineering - Undergraduate study; Study programme type: university; Study level: undergraduate; Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/baccalaurea) inženjer/inženjerka kemijskog inženjerstva)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Closed access
• Repository: Repository of Faculty of Chemical Engineering and Technology University of Zagreb
• Created on: 2016-09-08 12:34:36