Farmaceutska skrb kod pacijenata na terapiji statinima

master's thesis

• Title (english): Pharmaceutical care for patients on statins therapy
• Author: Marija Raguž
• Mentor: Lidija Bach-Rojecky (mentor)
• Committee member: Lidija Bach-Rojecky (predsjednik povjerenstva)
• Committee member: Renata Jurišić Grubešić (član povjerenstva)
• Committee member: Živka Juričić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Centre for applied pharmacy); Zagreb
• Defense date and country: 2016-01-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Hiperlipidemija je jedan od najvažnijih rizičnih čimbenika za razvoj bolesti kardiovaskularnog sustava koje su najveći uzročnici smrtnosti u svijetu. Statini su najvažnija skupina lijekova u terapiji hiperlipidemije. Zbog svoje učinkovitosti, trenutno spadaju među najpropisivanije lijekove u cijelom svijetu. Cilj ovog diplomskog rada bio je proširiti znanje o interakcijama statina s drugim lijekovima posebice onih koje mogu imati klinički značajne posljedice te istaknuti mogućnosti za uključivanje farmaceuta-ljekarnika u izbjegavanje, prepoznavanje i rješavanje terapijskih problema, kao i savjetovanje bolesnika koji uzimaju
statine.
U eksperimentalnom dijelu diplomskog rada analizirano je 75 farmakoterapijskih slučajeva iz farmaceutske prakse koji su sadržavali statine i pokazano je da su interakcije statina s drugim lijekovima u kliničkoj praksi vrlo česte i klinički značajne te potencijalno opasne. Pacijente je potrebno obavijestiti i uputiti o riziku hiperlipidemije i dobrobiti učinkovitog liječenja, osigurati im jasne pisane i usmene upute o liječenju, u dogovoru s liječnikom prilagoditi liječenje pacijentovom načinu života i potrebama te pojednostaviti liječenje smanjenjem broja lijekova. Sve pacijente koji primjenjuju statine treba pažljivije pratiti ako se u
terapiju uvodi novi lijek ili mijenja doza postojećeg lijeka, a pogotovo u slučaju određenih lijekova za koje je poznat rizik od ulaska u interakcije. Farmaceuti nadzorom nad terapijom, pravovremenim reagiranjem i savjetovanjem pacijenata mogu spriječiti interakcije te smanjiti njihove neželjene posljedice.

Abstract (english)

Hyperlipidemia is one of the most important risk factors for cardiovascular disease, which is the greatest cause of mortality in the world. Statins are the most important group of drugs in the treatment of hyperlipidemia. Because of its effectiveness, they are among the most widely prescribed drugs in the world. The aim of this thesis has been to expand knowledge of the interactions of statins with other drugs, especially those that may have clinical consequences and highlight the opportunities for involvement of pharmacists in avoiding, recognizing and solving therapeutic problems and counseling patients who are taking statins.
In the experimental part of thesis has been analyzed 75 cases of pharmacotherapeutical cases from pharmaceutical practice that were containing statins and it has been shown that the interaction of statins with other drugs in the clinical practice are very common and clinically significant and potentially dangerous. Patients should be informed and instructed about the risk of hyperlipidemia and well-being of an effective treatment, provide them with clear written and oral instructions about treatment, in consultation with a physician adjust the treatment to the patient's lifestyle and needs and also simplify treatment by reducing the number of drugs. All patients that are being administered a statin should be monitored more closely if a new medicine is introduced into the treatment or the dose of the current medication is changing, especially in the case of a drugs which are known risk of entering in interactions. Pharmacist supervision of
therapy, timely interventions and counseling of patients can inhibit the interactions and reduce their adverse consequences.

• Keywords: hiperlipidemija; antihiperlipemici; statini; interakcije lijekova; farmaceutska skrb
• Keywords (english): hyperlipidemia; antihyperlipidemics; statins; drug interaction; pharmaceutical care
• Language: croatian
• URN:NBN: urn:nbn:hr:163:631496
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb
• Created on: 2016-06-10 15:39:14