Upotreba kurkume kod nefarmakoloških metoda liječenja osteoartritisa

master's thesis

• Title (english): Curcuma as non-pharmacological method of treatment of osteoarthritis
• Author: Nikolina Šarko
• Mentor: Dubravka Vitali Čepo (mentor)
• Committee member: Dubravka Vitali Čepo (predsjednik povjerenstva)
• Committee member: Marija Grdić Rajković (član povjerenstva)
• Committee member: Lovorka Vujić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of food chemistry); Zagreb
• Defense date and country: 2018-05-18, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Osteoartritis je kronična upalna bolest zglobova obilježena degeneracijom zglobne hrskavice i
okolne kosti što može uzrokovati bol i ukočenost te samim time određeni stupanj invalidnosti
pacijenta. Liječenje osteoartritisa je simptomatsko gdje farmakološka terapija uključuje primjenu
paracetamola, opioidnih analgetika, nesteroidnih protuupalnih lijekova (NSAID) te
intraartikularnih injekcija kortikosteroida i hijaluronske kiseline. Nedostatak navedene terapije jest
kontraindiciranost NSAID-a kod pacijenata koje se manifestiraju na gastrointestinalnom sustavu.
Kortikosteroidi, iako snažni protuupalni lijekovi, opetovanom primjenom mogu uzrokovati
oštećenje zgloba. Zbog toga se nameću novi koncepti u liječenju osteoartritisa, a kao jedna od
alternativa navode se nutraceutici. Nutraceutici imaju visok potencijal u liječenju osteoartritisa
zbog potencijalne učinkovitosti i dobrog sigurnosnog profila što je osnovna prednost primjene
takvih proizvoda. Tako je i kurkumin, glavna aktivna sastavnica biljke kurkume, molekula
pleiotropnih učinaka s odličnim sigurnosnim profilom i dokazane potentnosti u upalnim bolestima
kao što je osteoartritis gdje djeluje protuupalno i antioksidativno. Iako prirodni kurkumin ima
ograničenu terapijsku učinkovitost zbog slabe topljivosti i niske bioraspoloživosti, većina kliničkih
studija istražuje terapijsku učinkovitost formulacija s poboljšanom bioraspoloživošću. Daljnje
provođenje kliničkih studija može doprinijeti definiranju optimalnih terapijskih smjernica za
primjenu kurkumina u osteoartritisu kako bi se unaprijedila ljekarnička skrb oboljelih od te bolesti.

Abstract (english)

Osteoarthritis is a chronic inflammatory joint disease characterized by degeneration of the joint
cartilage and surrounding bone, which can cause pain and stiffness and thus a certain degree of
disability of the patient.Treatment of osteoarthritis is symptomatic where pharmacological therapy
involves the use of paracetamol, opioid analgesics, non-steroidal anti-inflammatory drugs
(NSAIDs) and intra-articular injections of corticosteroids and hyaluronic acid. The disadvantage of
mentioned therapy is the contraindication of NSAIDs in patients manifesting in the gastrointestinal
system. Corticosteroids, though potent anti-inflammatory drugs, can cause joint damage when
frequently used. That is why new concepts for osteoarthritis are being introduced and
nutraceuticals are mentioned as one of the alternatives. Nutraceuticals have a high potential in
treating osteoarthritis due to their potential efficacy and a good safety profile, which is the main
advantage of using such products. Curcumin, the main active turmeric ingredient, is a pleiotropic
molecule with an excellent safety profile and proven potency in inflammatory diseases such as
osteoarthritis where it acts as anti-inflammatory agent and as an antioxidant. Although natural
curcumin has limited therapeutic efficacy due to poor solubility and low bioavailability, most
clinical trials investigate the therapeutic efficacy of formulations with improved bioavailability.
Further clinical studies may contribute in defining optimal therapeutic guidelines for the use of
curcumin in osteoarthritis in order to improve pharmacological care of patients suffering from this
disease.

• Keywords: kurkuma; kurkumin; kurkuminoidi; osteoartritis; artritis; upala; bioraspoloživost; nutraceutik
• Keywords (english): curcuma; turmeric; curcumin; curcuminoids; osteoarthritis; arthritis; inflammation; bioavailability; nutraceutic
• Language: croatian
• URN:NBN: urn:nbn:hr:163:434916
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Repository: Repository of Faculty of Pharmacy and Biochemistry University of Zagreb
• Created on: 2018-12-03 12:06:39